Synonyms: (+/-)-dimethindene | dimethindene | dimethpyrindene | Fenistil® | Vibrocil®
dimetindene is an approved drug
Compound class:
Synthetic organic
Comment: Dimetindene is an orally active, selective histamine H1 receptor antagonist. It also has anticholinergic activity [1]. The INN specifies the racemic mixture of (R)- and (S)-enantiomers. We show the structure without specified stereochemistry to represent that mixture.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
Dimetindene is the active antihistaminic ingredient in anti-allergy medications sold around the world. It is not approved in the US or the UK. |
Mechanism Of Action and Pharmacodynamic Effects |
Dimetindene blocks the action of endogenous histamine, and provides temporary relief from negative histaminergic effects. |