emapalumab   Click here for help

GtoPdb Ligand ID: 9295

Synonyms: emapalumab-lzsg | Gamifant® | NI-0501 | NI0501
Approved drug Immunopharmacology Ligand
emapalumab is an approved drug (FDA (2018))
Compound class: Antibody
Comment: Emapalumab (NI-0501) is a fully human monoclonal antibody that targets interferon gamma (IFNγ).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. BLAST peptide anaylsis reveals identical matches with peptides claimed in patent WO2006109191, and in which NI-0501 is confirmed as an exemplary antibody [2].
Bioactivity Comments
IFNγ binding and neutralisation by NI-0501 and results of biological function studies are provided in patent WO2006109191 [2].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IFN-γ Primary target of this compound Hs Antibody Binding 9.1 pKd - 2
⤷ pKd 9.1 (Kd 7.32x10-10 M) [2]
Description: Measured using Biacore technology