fezakinumab   Click here for help

GtoPdb Ligand ID: 9281

Synonyms: ILV-094
Immunopharmacology Ligand
Compound class: Antibody
Comment: Fezakinumab is a fully human monoclonal anti-IL22 antibody being investigated for clinical antiinflammatory utility against acute and chronic conditions.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequences identical to those of the heavy and light variable regions of fezakinumab are claimed in patent US7811567, leading to identification of clone 356A11 as fezakinumab [1].
Bioactivity Comments
Fezakinumab shows cross-species reactivity, blocking IL-22 receptor activation and cellular proliferation induced by murine, monkey and rat IL-22 in addition to the human cytokine [1].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-22 Primary target of this compound Hs Antibody Binding 10.3 pKd - 1
⤷ pKd 10.3 (Kd 5.4x10-11 M) [1]
Description: Binding in an ELISA using immobilized human IL-22