peginterferon alfa-2b   Click here for help

GtoPdb Ligand ID: 7462

Synonyms: PegIntron® | Sylatron®
Approved drug Immunopharmacology Ligand
peginterferon alfa-2b is an approved drug (EMA (2000), FDA (2001))
Compound class: Peptide or derivative
Comment: Peginterferon alfa-2b is a pegylated interferon protein. Conjugation with polyethylene glycol (PEG) is a strategy commonly used to protect peptide drugs from in vivo proteolytic breakdown to increase their biological half-life and duration of action.
Peginterferon alfa-2b is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
Bioactivity Comments
As this drug is an interferon α analogue it will interact with the interferon-α/β receptor (IFNAR) as would the endogenous ligand. We have tagged the interferon α/β receptor 1 (IFNAR1- ligand binding subunit) and IFNAR (heterodimeric receptor) as primary drug targets, despite a lack of available affinity data.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
interferon α/β receptor 1 Primary target of this compound Hs Agonist Agonist - - - 2
⤷ [2]
Interferon-α/β receptor Primary target of this compound Hs Agonist Agonist - - - 2
⤷ [2]