anakinra   Click here for help

GtoPdb Ligand ID: 6972

Synonyms: antril | Kineret®
Approved drug Immunopharmacology Ligand
anakinra is an approved drug (FDA (no history prior to 2001), EMA (2002))
Compound class: Peptide or derivative
Comment: This drug is a recombinant, nonglycosylated form of the endogenous IL-1 receptor antagonist peptide with an additional methionine at the amino terminus compared to the endogenous peptide.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: anakinra

Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-1 receptor, type I Primary target of this compound Hs Inhibitor Inhibition 7.8 pKd - 1
⤷ pKd 7.8 (Kd 1.5x10-8 M) [1]