urocortin 3   Click here for help

GtoPdb Ligand ID: 928

Synonyms: JNJ-39588146 | JNJ-9588146 | RT-400 | stresscopin
Compound class: Endogenous peptide in human, mouse or rat
Comment: Urocortin-3 (stresscopin) is a corticotropin-releasing factor type 2 receptor (CRF2R) agonist. In clinical trial for decompensated heart failure it has demonstrated short-term, dose-dependent efficacy in improving cardiac index and systemic vascular resistance.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Synonyms Click here for help
JNJ-39588146 | JNJ-9588146 | RT-400 | stresscopin
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
UCN3 urocortin 3 Human Urocortin 3 (prepro-urocortin 3) SPC, UCNIII, urocortin 3 (stresscopin)
Database Links Click here for help
Specialist databases
GPCRdb Ligand urocortin 3
Other databases
Ensembl Gene ENSG00000178473 (Hs)
GtoPdb PubChem SID 135651909
Human Protein Atlas ENSG00000178473 (Hs)
PubChem SID 47205392 (Hs)
UniProtKB Q969E3 (Hs)
Wikipedia UCN3