CXCL12β   Click here for help

GtoPdb Ligand ID: 845

Synonyms: SDF-1β | stromal cell-derived factor-1 (SDF-1) | stromal cell-derived factor-1β
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that medaites their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms Click here for help
SDF-1β | stromal cell-derived factor-1 (SDF-1) | stromal cell-derived factor-1β
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CXCL12 C-X-C motif chemokine ligand 12 Human chemokine (C-X-C motif) ligand 12 chemokine (C-X-C motif) ligand 12, PBSF, SCYB12, SDF1, SDF-1a, SDF1A, SDF-1b, SDF1B, stromal cell-derived factor 1, TLSF-a, TLSF-b, TPAR1
Database Links Click here for help
Specialist databases
GPCRdb Ligand CXCL12beta
Other databases
Ensembl Gene ENSG00000107562 (Hs)
GtoPdb PubChem SID 135651882
Human Protein Atlas ENSG00000107562 (Hs)
OMIM 600835 (Hs)
RefSeq Protein NP_000600 (Hs)
UniProtKB P48061 (Hs)
Wikipedia SDF-1_(biology) (Hs)