ephrin-B3   Click here for help

GtoPdb Ligand ID: 4915

Abbreviated name: EFNB3
Synonyms: EPH-related receptor transmembrane ligand ELK-L3 | EPH-related receptor tyrosine kinase ligand 8
Compound class: Endogenous peptide in human, mouse or rat
Comment: Ephrin B3 is a cell surface transmembrane ligand for Eph receptors (receptor tyrosine kinases, including EPHA4, EPHA3 and EPHB4). EFNB2 and EFNB3 are exploited for infection by the zoonotic henipaviruses, Nipah virus (NiV) and Hendra virus (HeV) [1-2]. These viruses emerged from bats during the 1990s and have since caused a number of deadly outbreaks in humans and domesticated animals. NiV and HeV infections in humans cause both neurological and respiratory symptoms. The WHO considers NiV as an emergong pathogen, with potential to cause infection of epidemic proportion. NiV has high mortality and morbidity rates and there is no effective anti-viral therapy.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Ephrins
Synonyms Click here for help
EPH-related receptor transmembrane ligand ELK-L3 | EPH-related receptor tyrosine kinase ligand 8
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
EFNB3 ephrin B3 Human prepro-ephrin-B3 ephrin-B3, EPLG8, LERK-8
Database Links Click here for help
CATH/Gene3D 2.60.40.420
Ensembl Gene ENSG00000108947 (Hs)
GtoPdb PubChem SID 178101614
Human Protein Atlas ENSG00000108947 (Hs)
UniProtKB Q15768 (Hs)
Wikipedia EPHB3