biotin   Click here for help

GtoPdb Ligand ID: 4787

PDB Ligand
Compound class: Metabolite or derivative
Comment: Biotin is a water-soluble B-complex vitamin and is an essential co-factor in various metabolic chemical conversions involving biologic carboxylations and the transfer of carbon dioxide. Biotin is critical for cell growth, fatty acid production and fat and amino acid metabolism. Biotin is used as a nutritional supplement, and to correct dietary shortage or imbalance.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 103.73
Molecular weight 244.09
XLogP 0.46
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC(=O)CCCCC1SCC2C1NC(=O)N2
Isomeric SMILES OC(=O)CCCC[C@@H]1SC[C@H]2[C@@H]1NC(=O)N2
InChI InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChI Key YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Classification Click here for help
Compound class Metabolite or derivative
IUPAC Name Click here for help
5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
International Nonproprietary Names Click here for help
INN number INN
1203 biotin
Database Links Click here for help
CAS Registry No. 58-85-5 (source: Scifinder)
ChEBI CHEBI:15956
ChEMBL Ligand CHEMBL857
DrugBank Ligand DB00121
DrugCentral Ligand 373
GtoPdb PubChem SID 178101489
PubChem CID 171548
RCSB PDB Ligand BTN
Search Google for chemical match using the InChIKey YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Search Google for chemicals with the same backbone YBJHBAHKTGYVGT
Search PubMed clinical trials biotin
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Search PubMed titles/abstracts biotin
UniChem Compound Search for chemical match using the InChIKey YBJHBAHKTGYVGT-ZKWXMUAHSA-N
UniChem Connectivity Search for chemical match using the InChIKey YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Wikipedia Biotin