pioglitazone   Click here for help

GtoPdb Ligand ID: 2694

Synonyms: Actos® | Glustin® | pioglitazone HCl | U-72107A
Approved drug
pioglitazone is an approved drug (FDA (1999), EMA (2000))
Compound class: Synthetic organic
Comment: Pioglitazone is a thiazolidinedione class antihyperglycemic drug.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pioglitazone

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 93.59
Molecular weight 356.12
XLogP 2.34
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCc1ccc(nc1)CCOc1ccc(cc1)CC1SC(=O)NC1=O
Isomeric SMILES CCc1ccc(nc1)CCOc1ccc(cc1)CC1SC(=O)NC1=O
InChI InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
InChI Key HYAFETHFCAUJAY-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1999), EMA (2000))
IUPAC Name Click here for help
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
International Nonproprietary Names Click here for help
INN number INN
6343 pioglitazone
Synonyms Click here for help
Actos® | Glustin® | pioglitazone HCl | U-72107A
Database Links Click here for help
BindingDB Ligand 50049240
CAS Registry No. 111025-46-8
ChEBI CHEBI:8228
ChEMBL Ligand CHEMBL595
DrugBank Ligand DB01132
DrugCentral Ligand 2179
GtoPdb PubChem SID 135650829
PubChem CID 4829
Search Google for chemical match using the InChIKey HYAFETHFCAUJAY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HYAFETHFCAUJAY
Search PubMed clinical trials pioglitazone
Search PubMed titles pioglitazone
Search PubMed titles/abstracts pioglitazone
UniChem Compound Search for chemical match using the InChIKey HYAFETHFCAUJAY-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey HYAFETHFCAUJAY-UHFFFAOYSA-N
Wikipedia Pioglitazone