anandamide   Click here for help

GtoPdb Ligand ID: 2364

Synonyms: AEA | arachidonoyl ethanolamide | N-arachidonoylethanolamine
PDB Ligand
Compound class: Metabolite or derivative
Comment: Anandamide is an endogenous cannabinoid neurotransmitter found in animal and human organs, especially in the brain. It activates the cannabinoid receptors CB1 and CB2. Anandamide is also known to be an endogenous activator of the TRPV1 cation channel [3,13], which is involved in regulation of body temperature and nociception.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 17
Topological polar surface area 49.33
Molecular weight 347.28
XLogP 7.43
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO
Isomeric SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO
InChI InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
InChI Key LGEQQWMQCRIYKG-DOFZRALJSA-N
Classification Click here for help
Compound class Metabolite or derivative
IUPAC Name Click here for help
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
Synonyms Click here for help
AEA | arachidonoyl ethanolamide | N-arachidonoylethanolamine
Database Links Click here for help
Specialist databases
GPCRdb Ligand anandamide
Other databases
BindingDB Ligand 22988
CAS Registry No. 94421-68-8 (source: ChEBI)
ChEBI CHEBI:2700
ChEMBL Ligand CHEMBL15848
GtoPdb PubChem SID 135651438
PubChem CID 5281969
RCSB PDB Ligand E7Y
Search Google for chemical match using the InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Search Google for chemicals with the same backbone LGEQQWMQCRIYKG
UniChem Compound Search for chemical match using the InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
UniChem Connectivity Search for chemical match using the InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Wikipedia Anandamide

Product suppliers

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Tocris
Anandamide (links to external site)
Cat. No. 1339