GW274150 [Ligand Id: 9849] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL114551 (Gw-274150, GW274150) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
| GtoPdb | - | - | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2004) 47: 3320-3 [PMID:15163211] |
| ChEMBL | In vitro inhibition of human neuronal nitric oxide synthase. | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
| ChEMBL | Inhibition of human nNOS expressed in insect SF9 cells after 1 hr | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 336-343 [PMID:18024030] |
| Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
| ChEMBL | In vitro inhibition of human endothelial nitric oxide synthase. | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
| GtoPdb | - | - | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2004) 47: 3320-3 [PMID:15163211] |
| Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| ChEMBL | Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting | B | 5.85 | pIC50 | 1412.54 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4228-4232 [PMID:21684157] |
| ChEMBL | Inhibition of human inducible nitric oxide synthase | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 597-600 [PMID:10741561] |
| ChEMBL | Inhibition of human recombinant iNOS by microtiter plate assay | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3037-3040 [PMID:21482467] |
| ChEMBL | Inhibition of human iNOS expressed in human DLD1 cells after 1 hr | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 336-343 [PMID:18024030] |
| GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2004) 47: 3320-3 [PMID:15163211] |
| ChEMBL | In vitro inhibition of human Inducible nitric oxide synthase. | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
