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ChEMBL ligand: CHEMBL583042 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578] | ||||||||
ChEMBL | Inhibition of CIT | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
ChEMBL | Inhibition of JNK3 | B | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 6.07 | pKi | 852 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
GtoPdb | - | - | 6.07 | pKi | 852 | nM | Ki | J Med Chem (2009) 52: 6362-8 [PMID:19827834] |
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
ChEMBL | Inhibition of MEK1 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibition of FAK | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of MET | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of IKKi | B | 5.3 | pKi | >5000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
ChEMBL | Inhibition of IRAK1 | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
ChEMBL | Inhibition of IRAK4 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 after 10 mins by spectrophotometric coupled-enzyme assay | B | 8.7 | pKi | <2 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
GtoPdb | - | - | 8.7 | pKi | <2 | nM | Ki | J Med Chem (2009) 52: 6362-8 [PMID:19827834] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of P38alpha | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] | ||||||||
ChEMBL | Inhibition of MLK2 | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase kinase kinase 14/Mitogen-activated protein kinase kinase kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5888] [GtoPdb: 2074] [UniProtKB: Q99558] | ||||||||
ChEMBL | Inhibition of NIK | B | 5.3 | pKi | >5000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759] | ||||||||
ChEMBL | Inhibition of MEKK3 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
ChEMBL | Inhibition of TAK1 | B | 5.52 | pKi | 3000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
mitogen-activated protein kinase kinase kinase 8/Mitogen-activated protein kinase kinase kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4899] [GtoPdb: 2083] [UniProtKB: P41279] | ||||||||
ChEMBL | Inhibition of COT | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
ChEMBL | Inhibition of ROCK1 | B | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
ChEMBL | Inhibition of AKT3 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of AURA | B | 6.27 | pKi | 540 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
GtoPdb | - | - | 6.27 | pKi | 540 | nM | Ki | J Med Chem (2009) 52: 6362-8 [PMID:19827834] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of PLK1 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141] | ||||||||
ChEMBL | Inhibition of SGK1 | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
ChEMBL | Inhibition of NAK | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
ChEMBL | Inhibition of ITK | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
ChEMBL | Inhibition of FLT3 | B | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of SRC | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of SYK | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of KDR | B | 5.4 | pKi | >4000 | nM | Ki | J Med Chem (2009) 52: 6362-6368 [PMID:19827834] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]