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ChEMBL ligand: CHEMBL3421914 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
ChEMBL | Inhibition of human DDR1 kinase domain (601 to 913 residues) expressed in Sf9 cells by enzymatic kinase assay | B | 6.98 | pIC50 | 105 | nM | IC50 | J Med Chem (2015) 58: 3287-3301 [PMID:25569119] |
GtoPdb | In a Lanthascreen enzyme assay | - | 6.98 | pIC50 | 105 | nM | IC50 | ACS Chem Biol (2013) 8: 2145-50 [PMID:23899692] |
ChEMBL | Inhibition of human DDR1 in doxycycline-stimulated human U2OS cells assessed as inhibition of collagen-1-induced autophosphorylation incubated for 1 hr | B | 7.07 | pIC50 | 86 | nM | IC50 | J Med Chem (2015) 58: 3287-3301 [PMID:25569119] |
discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832] | ||||||||
GtoPdb | In a Lanthascreen enzyme assay | - | 6.38 | pIC50 | 413 | nM | IC50 | ACS Chem Biol (2013) 8: 2145-50 [PMID:23899692] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]