SP-4206 [Ligand Id: 9037] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL429852 (SP-4206)
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  • Interleukin-2 receptor subunit α/Interleukin-2 receptor alpha chain in Mouse [ChEMBL: CHEMBL3287] [GtoPdb: 1695] [UniProtKB: P01590]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Interleukin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5880] [UniProtKB: P60568]
ChEMBL Binding affinity to IL2 (unknown origin) by SPR assay B 7 pKd 100 nM Kd J Med Chem (2021) 64: 17496-17510 [PMID:34821503]
ChEMBL Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction B 7.22 pKi 60 nM Ki Nature (2007) 450: 1001-1009 [PMID:18075579]
ChEMBL Binding affinity to IL2 (unknown origin) assessed as inhibition of binding to IL2 receptor alpha B 7.22 pIC50 60 nM IC50 Med Chem Res (2013) 22: 5739-5751
Interleukin-2 receptor subunit α/Interleukin-2 receptor alpha chain in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3287] [GtoPdb: 1695] [UniProtKB: P01590]
ChEMBL Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay B 7.22 pIC50 60 nM IC50 J Med Chem (2004) 47: 3111-3130 [PMID:15163192]
ChEMBL Effective concentration required against phosphorylation of Mammary gland factor/STAT5 F 8.52 pEC50 3 nM EC50 J Med Chem (2004) 47: 3111-3130 [PMID:15163192]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]