ADL5859 [Ligand Id: 9004] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL494480 (Adl-5859) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells | B | 9.08 | pKi | 0.84 | nM | Ki | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
| GtoPdb | - | - | 9.08 | pKi | 0.84 | nM | Ki | J Med Chem (2008) 51: 5893-6 [PMID:18788723] |
| ChEMBL | Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 7.7 | pEC50 | 20 | nM | EC50 | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel in HEK293 cells by voltage-clamp method | B | 4.11 | pIC50 | 78000 | nM | IC50 | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
| κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| GtoPdb | - | - | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2008) 51: 5893-6 [PMID:18788723] |
| μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 7.49 | pKi | 32 | nM | Ki | J Med Chem (2008) 51: 5893-6 [PMID:18788723] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
