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ChEMBL ligand: CHEMBL358725 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
ChEMBL | Inhibitory activity against of Caspase-1 | B | 5.41 | pKi | 3900 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
Caspase 2/Caspase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4884] [GtoPdb: 1618] [UniProtKB: P42575] | ||||||||
ChEMBL | Inhibitory activity against of Caspase-2 | B | 6.02 | pKi | 960 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
GtoPdb | - | - | 6.02 | pKi | 960 | nM | Ki | J Med Chem (2002) 45: 5005-22 [PMID:12408711] |
Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
GtoPdb | - | - | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2002) 45: 5005-22 [PMID:12408711] |
ChEMBL | Inhibitory activity against Caspase-3 | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
Caspase 4/Caspase-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2226] [GtoPdb: 1620] [UniProtKB: P49662] | ||||||||
ChEMBL | Inhibitory activity against Caspase-4 | B | 4.04 | pKi | 92000 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
Caspase 5/Caspase-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3131] [GtoPdb: 1621] [UniProtKB: P51878] | ||||||||
ChEMBL | Inhibitory activity against Caspase-5 | B | 4.66 | pKi | 22000 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
Caspase 6/Caspase-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308] [GtoPdb: 1622] [UniProtKB: P55212] | ||||||||
ChEMBL | Inhibitory activity against Caspase-6 | B | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210] | ||||||||
ChEMBL | Inhibitory activity against Caspase-7 | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
GtoPdb | - | - | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2002) 45: 5005-22 [PMID:12408711] |
Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790] | ||||||||
ChEMBL | Inhibitory activity against Caspase-8 | B | 6.06 | pKi | 880 | nM | Ki | J Med Chem (2002) 45: 5005-5022 [PMID:12408711] |
GtoPdb | - | - | 6.06 | pKi | 880 | nM | Ki | J Med Chem (2002) 45: 5005-22 [PMID:12408711] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]