compound 3 [PMID: 23849879] [Ligand Id: 8488] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1413622
  • kallikrein related peptidase 14/Kallikrein 14 in Human [ChEMBL: CHEMBL2641] [GtoPdb: 2866] [UniProtKB: Q9P0G3]
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  • kallikrein related peptidase 5/Kallikrein 5 in Human [ChEMBL: CHEMBL4447] [GtoPdb: 2375] [UniProtKB: Q9Y337]
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  • kallikrein related peptidase 7/Kallikrein 7 in Human [ChEMBL: CHEMBL2443] [GtoPdb: 2377] [UniProtKB: P49862]
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  • ST14 transmembrane serine protease matriptase /Matriptase in Human [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
kallikrein related peptidase 14/Kallikrein 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2641] [GtoPdb: 2866] [UniProtKB: Q9P0G3]
ChEMBL Inhibition of human kallikrein 14 measured after 15 mins at pH 8 by fluorescence assay B 5.89 pIC50 1290 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879]
GtoPdb - - 5.89 pIC50 1290 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879]
kallikrein related peptidase 5/Kallikrein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4447] [GtoPdb: 2375] [UniProtKB: Q9Y337]
ChEMBL Inhibition of human kallikrein 5 measured after 15 mins at pH 8 by double-reciprocal plot analysis B 5.36 pKi 4400 nM Ki Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879]
ChEMBL Inhibition of human kallikrein 5 measured after 15 mins at pH 8 by fluorescence assay B 6.57 pIC50 270 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879]
GtoPdb - - 6.57 pIC50 270 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879]
kallikrein related peptidase 7/Kallikrein 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2443] [GtoPdb: 2377] [UniProtKB: P49862]
ChEMBL Inhibition of human kallikrein 7 measured after 15 mins at pH 8 by fluorescence assay B 7.4 pIC50 40 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879]
GtoPdb - - 7.4 pIC50 40 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879]
ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6]
GtoPdb - - 6.24 pIC50 570 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-51 [PMID:23849879]
ChEMBL Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay B 6.24 pIC50 570 nM IC50 Bioorg Med Chem Lett (2013) 23: 4547-4551 [PMID:23849879]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]