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ChEMBL ligand: CHEMBL571858 (WAY-208466) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells | B | 5.3 | pIC50 | <5000 | nM | IC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
ChEMBL | Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
ChEMBL | Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells | B | 6.45 | pIC50 | 351 | nM | IC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells | B | 6.19 | pIC50 | 644 | nM | IC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
ChEMBL | Displacement of [3H]LSD from human HT6 receptor expressed in human HeLa cells | B | 8.31 | pKi | 4.9 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6935-6938 [PMID:19884004] |
ChEMBL | Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HeLa cells | B | 8.32 | pKi | 4.8 | nM | Ki | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
ChEMBL | Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells by scintillation counter | B | 8.32 | pKi | 4.8 | nM | Ki | J Med Chem (2015) 58: 7901-7912 [PMID:26099069] |
GtoPdb | - | - | 8.32 | pKi | 4.8 | nM | Ki | Bioorg Med Chem (2009) 17: 5153-63 [PMID:19523834] |
ChEMBL | Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay | F | 8.14 | pEC50 | 7.3 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 6935-6938 [PMID:19884004] |
ChEMBL | Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA | F | 8.14 | pEC50 | 7.3 | nM | EC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
ChEMBL | Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay | B | 8.14 | pEC50 | 7.3 | nM | EC50 | J Med Chem (2015) 58: 7901-7912 [PMID:26099069] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
ChEMBL | Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells | B | 5.32 | pIC50 | 4764 | nM | IC50 | Bioorg Med Chem (2009) 17: 5153-5163 [PMID:19523834] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]