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ChEMBL ligand: CHEMBL201307 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Inhibitory activity against JNK1alpha | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibitory activity against CDK2 | B | 4.21 | pIC50 | 62000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibitory activity against EGFR | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
ChEMBL | Inhibition of EGFR kinase | B | 6.1 | pIC50 | 800 | nM | IC50 | Nat Chem Biol (2006) 2: 358-364 [PMID:16783341] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibitory activity against FAK | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibitory activity against human hERG receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibitory activity against IGFR | B | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibitory activity against p38-alpha MAPK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
GtoPdb | - | - | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2006) 49: 955-70 [PMID:16451062] |
ChEMBL | Inhibition of Aurora A kinase activity | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
ChEMBL | Inhibition of aurora A kinase | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2009) 52: 2629-2651 [PMID:19320489] |
ChEMBL | Inhibition of Aurora A kinase | B | 9 | pIC50 | <1 | nM | IC50 | Nat Chem Biol (2006) 2: 358-364 [PMID:16783341] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
GtoPdb | - | - | 8.15 | pIC50 | <7 | nM | IC50 | J Med Chem (2006) 49: 955-70 [PMID:16451062] |
ChEMBL | Inhibition of aurora B kinase | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2009) 52: 2629-2651 [PMID:19320489] |
ChEMBL | Inhibition of Aurora B kinase | B | 8.15 | pIC50 | 7 | nM | IC50 | Nat Chem Biol (2006) 2: 358-364 [PMID:16783341] |
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] | ||||||||
ChEMBL | Inhibitory activity against CSK | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibitory activity against JAK3 | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibitory activity against SRC | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibitory activity against KDR | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2006) 49: 955-970 [PMID:16451062] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]