6-fluoromevalonate pyrophosphate [Ligand Id: 7996] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1160328
  • diphosphomevalonate decarboxylase/Mevalonate pyrophosphate decarboxylase in Human [ChEMBL: CHEMBL4340] [GtoPdb: 642] [UniProtKB: P53602]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
diphosphomevalonate decarboxylase/Mevalonate pyrophosphate decarboxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4340] [GtoPdb: 642] [UniProtKB: P53602]
GtoPdb - - 7.43 pKi 37 nM Ki Bioorg Med Chem Lett (1996) 6: 2091-2096
ChEMBL Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylase B 7.43 pKi 37 nM Ki Bioorg Med Chem Lett (1996) 6: 2091-2096

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]