ChEMBL ligand: CHEMBL134074
CCR2/C-C chemokine receptor type 2 in Human [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CCR2/C-C chemokine receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597]
ChEMBL	Binding affinity of compound (10 uM) towards T292A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	5.2	pKi	6309.57	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards H121A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	5.6	pKi	2511.89	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards D284A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	6.07	pKi	851.14	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards T290A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	6.28	pKi	524.81	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards H121F receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	6.35	pKi	446.68	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards WT receptor variant (mutant C-C chemokine receptor type 2) using radioligand [125I]MCP-1 in HEK 293 cells	B	6.66	pKi	218.78	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding displacement of [125I]MCP-1 (0.14 nM) was measured on CHO cell membranes expressing human CCR2 (C-C chemokine receptor type 2)	B	6.68	pKi	208.93	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
GtoPdb	-	-	6.7	pKi	-	-	-	J Med Chem (2003) 46: 4070-86 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards Q288A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	6.76	pKi	173.78	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Binding affinity of compound (10 uM) towards Y49F receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells	B	7.23	pKi	58.88	nM	Ki	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]
ChEMBL	Inhibitory activity against C-C chemokine receptor type 2 (antagonist activity)	F	7.05	pIC50	89	nM	IC50	J Med Chem (2003) 46: 4070-4086 [PMID:12954060]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]