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ChEMBL ligand: CHEMBL64905 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
ChEMBL | Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicans | B | 9.66 | pIC50 | 0.22 | nM | IC50 | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
ChEMBL | Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liver | B | 5.82 | pKi | 1500 | nM | Ki | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
ChEMBL | Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liver | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
ChEMBL | Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from pig liver | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
GtoPdb | - | - | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1997) 40: 201-9 [PMID:9003518] |
ChEMBL | Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liver | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
ChEMBL | Inhibition of rat OSC | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem (2007) 15: 4674-4699 [PMID:17521912] |
Lanosterol synthase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075056] [UniProtKB: Q04782] | ||||||||
ChEMBL | Inhibition of Candida albicans OSC | B | 9.66 | pIC50 | 0.22 | nM | IC50 | Bioorg Med Chem (2007) 15: 4674-4699 [PMID:17521912] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]