compound 3 [PMID: 9003518] [Ligand Id: 6720] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL64905
  • lanosterol synthase/Lanosterol synthase in Human [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449]
  • lanosterol synthase/Lanosterol synthase in Rat [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450]
  • Lanosterol synthase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL1075056] [UniProtKB: Q04782]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449]
ChEMBL Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicans B 9.66 pIC50 0.22 nM IC50 J Med Chem (1997) 40: 201-209 [PMID:9003518]
lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450]
ChEMBL Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liver B 5.82 pKi 1500 nM Ki J Med Chem (1997) 40: 201-209 [PMID:9003518]
ChEMBL Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liver B 7.43 pKi 37 nM Ki J Med Chem (1997) 40: 201-209 [PMID:9003518]
ChEMBL Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from pig liver B 5.64 pIC50 2300 nM IC50 J Med Chem (1997) 40: 201-209 [PMID:9003518]
GtoPdb - - 7.3 pIC50 50 nM IC50 J Med Chem (1997) 40: 201-9 [PMID:9003518]
ChEMBL Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liver B 7.3 pIC50 50 nM IC50 J Med Chem (1997) 40: 201-209 [PMID:9003518]
ChEMBL Inhibition of rat OSC B 7.3 pIC50 50 nM IC50 Bioorg Med Chem (2007) 15: 4674-4699 [PMID:17521912]
Lanosterol synthase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075056] [UniProtKB: Q04782]
ChEMBL Inhibition of Candida albicans OSC B 9.66 pIC50 0.22 nM IC50 Bioorg Med Chem (2007) 15: 4674-4699 [PMID:17521912]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]