Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL437027 (Bombesin, Bombesin 14) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
BB2 receptor/Gastrin releasing peptide receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4959] [GtoPdb: 39] [UniProtKB: P30550] | ||||||||
GtoPdb | - | - | 8.85 | pKi | 1.4 | nM | Ki |
J Pharmacol Exp Ther (1999) 290: 1202-11 [PMID:10454496]; Mol Pharmacol (1995) 47: 10-20 [PMID:7838118] |
ChEMBL | In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin. | B | 9.82 | pKi | 0.15 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586] |
ChEMBL | Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cells | B | 9.82 | pKi | 0.15 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2617-2622 |
ChEMBL | Displacement of [125I]-Tyr4-BBN from human GRPR overexpressed in human T47D cells | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 687-692 [PMID:23265893] |
GtoPdb | - | - | 10.15 | pIC50 | 0.07 | nM | IC50 | Peptides (2011) 32: 1685-99 [PMID:21729729] |
ChEMBL | Displacement of 125I[Tyr4]-bombesin from GRPR expressed in human PC3 cells | B | 9.59 | pEC50 | 0.26 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 2424-2427 [PMID:18329268] |
BB2 receptor in Mouse [GtoPdb: 39] [UniProtKB: P21729] | ||||||||
GtoPdb | - | - | 9.05 | pKi | 0.9 | nM | Ki | Mol Pharmacol (1995) 47: 10-20 [PMID:7838118] |
BB2 receptor in Rat [GtoPdb: 39] [UniProtKB: P52500] | ||||||||
GtoPdb | - | - | 8.39 | pKi | 4.1 | nM | Ki | Mol Pharmacol (1995) 47: 10-20 [PMID:7838118] |
BB1 receptor/Neuromedin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3636] [GtoPdb: 38] [UniProtKB: P28336] | ||||||||
GtoPdb | - | - | 7.49 | pKi | 32 | nM | Ki |
J Pharmacol Exp Ther (1999) 290: 1202-11 [PMID:10454496]; Mol Pharmacol (1995) 47: 10-20 [PMID:7838118] |
ChEMBL | Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells | F | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586] |
ChEMBL | Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 2617-2622 |
GtoPdb | - | - | 8.75 | pIC50 | 1.77 | nM | IC50 | Peptides (2011) 32: 1685-99 [PMID:21729729] |
BB1 receptor in Rat [GtoPdb: 38] [UniProtKB: P24053] | ||||||||
GtoPdb | - | - | 7.68 | pKi | 21 | nM | Ki |
J Pharmacol Exp Ther (1999) 290: 1202-11 [PMID:10454496]; Mol Pharmacol (1995) 47: 10-20 [PMID:7838118] |
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] | ||||||||
ChEMBL | Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 687-692 [PMID:23265893] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]