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ChEMBL ligand: CHEMBL191384 (AS-601245) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Inhibition of JNK1 in the presence of 20uM ATP | B | 5.59 | pIC50 | 2600 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
ChEMBL | Inhibition of human JNK1 | B | 6.82 | pIC50 | 150 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of human JNK1 by radiometric assay | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem (2008) 16: 4715-4732 [PMID:18313304] |
ChEMBL | Inhibition of JNK1 | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2010) 53: 3005-3012 [PMID:20146479] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of JNK2 in the presence of 20uM ATP | B | 5.3 | pIC50 | 5000 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
ChEMBL | Inhibition of human JNK2 | B | 6.66 | pIC50 | 220 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of JNK2 | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2010) 53: 3005-3012 [PMID:20146479] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
ChEMBL | Inhibition of JNK3 | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2010) 53: 419-431 [PMID:19947601] |
GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | |
ChEMBL | Inhibition of JNK3 | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem (2007) 15: 4256-4264 [PMID:17451961] |
ChEMBL | Inhibition of human JNK3 | B | 7.15 | pIC50 | 70 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of JNK3 | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2010) 53: 3005-3012 [PMID:20146479] |
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
ChEMBL | Inhibition of DYRK2 in the presence of 50uM ATP | B | 6.52 | pIC50 | 300 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta in the presence of 20uM ATP | B | 7.4 | pIC50 | 40 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
ChEMBL | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay | B | 7 | pIC50 | <100 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4108-4114 [PMID:21632247] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of PIM1 in the presence of 20uM ATP | B | 7.1 | pIC50 | 80 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
ChEMBL | Inhibition of PIM3 in the presence of 5uM ATP | B | 7.52 | pIC50 | 30 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]