ChEMBL ligand: CHEMBL596674
Protein-glutamine gamma-glutamyltransferase in Guinea pig [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8] There should be some charts here, you may need to enable JavaScript!
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] There should be some charts here, you may need to enable JavaScript!
transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Protein-glutamine gamma-glutamyltransferase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8]
ChEMBL	Inhibition of guinea pig liver transglutaminase	B	5.4	pIC50	4000	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1141-1144 [PMID:20053561]
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7]
ChEMBL	MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate	F	5.09	pIC50	8100	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate	F	6.24	pIC50	580	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL	Inhibition of JAK3 (unknown origin) by ELISA	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4229-4237 [PMID:28844493]
GtoPdb	-	-	7.1	pIC50	79	nM	IC50	Bioorg Med Chem Lett (2000) 10: 575-9 [PMID:10741557]
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb	-	-	4.4	pIC50	39810	nM	IC50	Bioorg Med Chem Lett (2000) 10: 575-9 [PMID:10741557]
transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980]
GtoPdb	In the absence of DTT.	-	8	pIC50	10	nM	IC50	Chem Biol (2008) 15: 969-78 [PMID:18804034]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]