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ChEMBL ligand: CHEMBL602937 (Fascaplysin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
ChEMBL | Non-competitive inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk reciprocal plot analysis | B | 5.64 | pKi | 2280 | nM | Ki | Medchemcomm (2012) 3: 1098-1103 |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 30 mins by Ellman's method | B | 5.83 | pIC50 | 1490 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
cyclin dependent kinase 4/CDK4/Cyclin D3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038472] [GtoPdb: 1976] [UniProtKB: P11802, P30281] | ||||||||
ChEMBL | Inhibition of CDK4/cyclin-D3 (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
GtoPdb | CDK4/cyclin D1 complex | - | 6.46 | pIC50 | 350 | nM | IC50 | Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815] |
cyclin dependent kinase 6/CDK6/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111455] [GtoPdb: 1978] [UniProtKB: P24385, Q00534] | ||||||||
ChEMBL | Inhibition of CDK6/cyclin-D1 (unknown origin) | B | 5.47 | pIC50 | 3400 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
cyclin dependent kinase 6/CDK6/cyclin D2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301386] [GtoPdb: 1978] [UniProtKB: P30279, Q00534] | ||||||||
ChEMBL | Inhibition of CDK6/cyclin-D2 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
ChEMBL | Non-competitive inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate by Lineweaver-Burk reciprocal plot analysis | B | 4.31 | pKi | 48490 | nM | Ki | Medchemcomm (2012) 3: 1098-1103 |
ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate after 30 mins by Ellman's method | B | 4.04 | pIC50 | 90470 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
ChEMBL | Inhibition of CDK1/cyclin-B (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
ChEMBL | Inhibition of CDK2/cyclin-E (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
ChEMBL | Inhibition of CDK4/cyclin-D1 (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
GtoPdb | CDK4/cyclin D1 complex | - | 6.46 | pIC50 | 350 | nM | IC50 | Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301385] [GtoPdb: 1976] [UniProtKB: P11802, P30279] | ||||||||
ChEMBL | Inhibition of CDK4/cyclin-D2 (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
GtoPdb | CDK4/cyclin D1 complex | - | 6.46 | pIC50 | 350 | nM | IC50 | Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibition of CDK5/p-35 (unknown origin) | B | 4.7 | pIC50 | 20000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]