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ChEMBL ligand: CHEMBL296455 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811] | ||||||||
ChEMBL | Inhibitory activity against beta-lactamase | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2002) 45: 1712-1722 [PMID:11931626] |
chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895] | ||||||||
ChEMBL | Inhibitory activity against chymotrypsinogen | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (2002) 45: 1712-1722 [PMID:11931626] |
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
ChEMBL | Equilibrium binding constant for EPH receptor B2 | B | 4.71 | pKd | 19500 | nM | Kd | J Med Chem (2005) 48: 3221-3230 [PMID:15857128] |
ChEMBL | Inhibition of EPH receptor B2 using ELISA | B | 4.56 | pIC50 | 27500 | nM | IC50 | J Med Chem (2005) 48: 3221-3230 [PMID:15857128] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
ChEMBL | Inhibition Assay: Inhibition of various kinase enzyme. | B | 5.43 | pIC50 | 3750 | nM | IC50 | US-9422297-B2. Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof (2016) |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3337] [GtoPdb: 1813] [UniProtKB: P35918] | ||||||||
ChEMBL | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | B | 6.1 | pIC50 | 794.33 | nM | IC50 | J Med Chem (2000) 43: 3020-3032 [PMID:10956210] |
GtoPdb | - | - | 6.1 | pIC50 | 794 | nM | IC50 | J Med Chem (2000) 43: 3020-32 [PMID:10956210] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]