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ChEMBL ligand: CHEMBL832 (Anturan, Anturane, NSC-75925, Sulfinpyrazone, Sulphinpyrazone) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462] | ||||||||
GtoPdb | - | - | 5 | pIC50 | - | - | - | J Biomol Screen (2005) 10: 374-82 [PMID:15964939] |
ChEMBL | Antagonist activity at FPR1 | F | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2991-2997 [PMID:21486695] |
ABCC5/Multidrug resistance-associated protein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of PMEA efflux (PMEA: 1 uM) in MRP5-expressing MDCKII cells | F | 4 | pIC50 | <100000 | nM | IC50 | Proc Natl Acad Sci U S A (2000) 97: 7476-7481 [PMID:10840050] |
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] | ||||||||
ChEMBL | Inhibition of NAPRT (unknown origin) | B | 9.3 | pKi | 0.5 | nM | Ki | WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (null) |
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37] | ||||||||
GtoPdb | - | - | 4 | pIC50 | 100000 | nM | IC50 | Drug Metab Dispos (2007) 35: 981-6 [PMID:17325024] |
ChEMBL | Inhibition of human URAT1-mediated urate uptake in HEK293 cells | B | 4 | pIC50 | 100000 | nM | IC50 | Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]