Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1800685 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
ChEMBL | GPCRScan assay: inhibition of Alpha1B | B | 5.49 | pKi | 3235.94 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of Alpha1B | B | 5.49 | pKi | 3230.73 | nM | Ki | Data for DCP probe PPTN |
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
ChEMBL | GPCRScan assay: inhibition of Alpha2B | B | 5.59 | pKi | 2570.4 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of Alpha2B | B | 5.59 | pKi | 2561.53 | nM | Ki | Data for DCP probe PPTN |
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
ChEMBL | GPCRScan assay: inhibition of Beta3 | B | 5.53 | pKi | 2951.21 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of Beta3 | B | 5.53 | pKi | 2918.77 | nM | Ki | Data for DCP probe PPTN |
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
ChEMBL | Agonist activity at CB1 receptor (unknown origin) | B | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
ChEMBL | Antagonist activity at CB1 receptor (unknown origin) | B | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
ChEMBL | Antagonist activity at rat brain CB2 receptor expressed in HEK-Flp-In cells in presence of [3H]CP55940 measured after overnight incubation by Bright-Glo luminescence assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1281-1286 [PMID:32551012] |
ChEMBL | Antagonist activity at rat brain CB1 receptor expressed in HEK-Flp-In cells in presence of [3H]CP55940 measured after overnight incubation by Bright-Glo luminescence assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1281-1286 [PMID:32551012] |
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
ChEMBL | Agonist activity at CB2 receptor (unknown origin) | B | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
ChEMBL | Antagonist activity at CB2 receptor (unknown origin) | B | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Binding affinity to human delta opioid receptor expressed in HEK cells by PDSP assay | B | 5.56 | pKi | 2750 | nM | Ki | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
ChEMBL | Binding affinity to DOR (unknown origin) | B | 5.56 | pKi | 2750 | nM | Ki | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
ChEMBL | GPCRScan assay: inhibition of D1 | B | 5 | pKi | 10000 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of D1 | B | 5 | pKi | 10000 | nM | Ki | Data for DCP probe PPTN |
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
ChEMBL | Binding affinity to DRD3 (unknown origin) | B | 5.17 | pKi | 6790 | nM | Ki | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
ChEMBL | GPCRScan assay: inhibition of D3 | B | 6.05 | pKi | 891.25 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of D3 | B | 6.05 | pKi | 884.3 | nM | Ki | Data for DCP probe PPTN |
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
ChEMBL | Binding affinity to rat D3 dopamine receptor expressed in HEK293T cells by PDSP assay | B | 5.17 | pKi | 6790 | nM | Ki | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
ChEMBL | GPCRScan assay: inhibition of D5 | B | 5.55 | pKi | 2819.68 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of D5 | B | 5.55 | pKi | 2818.38 | nM | Ki | Data for DCP probe PPTN |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of full length human ERG expressed in CHO cells by patch-clamp method | B | 4.52 | pEC50 | >30000 | nM | EC50 | J Med Chem (2021) 64: 5099-5122 [PMID:33787273] |
P2Y14 receptor in Human [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
GtoPdb | - | - | 10.1 | pKi | 0.43 | nM | KB | Mol Pharmacol (2013) 84: 41-9 [PMID:23592514] |
P2Y14 receptor/P2Y purinoceptor 14 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770046] [GtoPdb: 330] [UniProtKB: Q9ESG6] | ||||||||
ChEMBL | Inhibition of mouse P2Y14 receptor in presence of 2% HSA | B | 7.46 | pKi | 35 | nM | Ki | Eur J Med Chem (2019) 175: 34-39 [PMID:31071548] |
ChEMBL | Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from HA-tagged mouse P2Y14 expressed in HEK293 cells measured after 30 mins by FACScalibur flow cytometry analysis | B | 7.67 | pIC50 | 21.6 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1281-1286 [PMID:32551012] |
ChEMBL | Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins by flow cytomtery based competitive fluorescence assay | B | 7.67 | pIC50 | 21.6 | nM | IC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
P2Y14 receptor/P2Y purinoceptor 14 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295660] [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
ChEMBL | Antagonist activity at P2Y14R in rat C6 cells assessed as suppression of UDP-glucose-mediated inhibition of forskolin-stimulated [3H]cyclic-AMP accumulation after 15 mins in presence of [3H]-adenine | B | 9.4 | pKi | 0.4 | nM | Ki | J Med Chem (2018) 61: 4860-4882 [PMID:29767967] |
P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
ChEMBL | Antagonist activity human P2Y1R expressed in human 1321N1 cells assessed as inhibition of 2MeSADP-induced [3H]inositol phosphate accumulation after 30 mins by liquid scintillation counting method | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
ChEMBL | Antagonist activity human P2Y11R expressed in human 1321N1 cells assessed as inhibition of ATP-induced [3H]inositol phosphate accumulation after 30 mins by liquid scintillation counting method | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
ChEMBL | Binding assay with 2% HSA | B | 7.46 | pKi | 35 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | Binding assay (no HSA) | B | 8.64 | pKi | 2.3 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | Antagonist activity at human P2Y14 expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP accumulation incubated for 15 mins in presence of IBMX | F | 9.37 | pKi | 0.43 | nM | Ki | J Med Chem (2022) 65: 3434-3459 [PMID:35113556] |
GtoPdb | - | - | 10.1 | pKi | 0.43 | nM | KB | Mol Pharmacol (2013) 84: 41-9 [PMID:23592514] |
ChEMBL | Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins at pH 6 by flow cytomtery based competitive fluorescence assay | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
ChEMBL | Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins at pH 6.5 by flow cytomtery based competitive fluorescence assay | B | 7.84 | pIC50 | 14.5 | nM | IC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
ChEMBL | Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins at pH 7 by flow cytomtery based competitive fluorescence assay | B | 8.01 | pIC50 | 9.75 | nM | IC50 | J Med Chem (2020) 63: 9563-9589 [PMID:32787142] |
ChEMBL | Inhibition of fluorescent antagonist binding to human P2Y14 expressed in CHO cells incubated for 30 mins | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2022) 65: 3434-3459 [PMID:35113556] |
ChEMBL | Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method | B | 8.1 | pIC50 | 7.96 | nM | IC50 | J Med Chem (2018) 61: 4860-4882 [PMID:29767967] |
ChEMBL | Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from human P2Y14 expressed in CHO cells measured after 30 mins by FACScalibur flow cytometry analysis | B | 8.22 | pIC50 | 6 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1281-1286 [PMID:32551012] |
ChEMBL | Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)-phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate from human P2Y14R expressed in CHO cells measured after 15 mins by flow cytometric analysis | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
ChEMBL | Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhibition of cAMP production incubated for 15 mins by competitive enzyme-linked immunoassay | F | 8.7 | pIC50 | 1.98 | nM | IC50 | Eur J Med Chem (2019) 181: 111564-111564 [PMID:31376563] |
ChEMBL | Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo assay | F | 8.7 | pIC50 | 1.98 | nM | IC50 | Eur J Med Chem (2021) 216: 113313-113313 [PMID:33667846] |
ChEMBL | FLIPR assay | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Data for DCP probe PPTN |
ChEMBL | Antagonist activity human P2Y14R expressed in African green monkey COS7 cells assessed as inhibition of UDPG-induced [3H]inositol phosphate accumulation after 30 mins by liquid scintillation counting method | F | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
ChEMBL | Antagonist activity human P2Y2R expressed in human 1321N1 cells assessed as inhibition of UTP-induced [3H]inositol phosphate accumulation after 30 mins by liquid scintillation counting method | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
ChEMBL | Antagonist activity human P2Y4R expressed in human 1321N1 cells assessed as inhibition of UTP-induced [3H]inositol phosphate accumulation after 30 mins by liquid scintillation counting method | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
ChEMBL | Antagonist activity human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced [3H]inositol phosphate accumulation after 30 mins by liquid scintillation counting method | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 6149-6168 [PMID:27331270] |
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] | ||||||||
ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 5.95 | pKi | 1122.02 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of Sigma 2 | B | 5.95 | pKi | 1120.99 | nM | Ki | Data for DCP probe PPTN |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
ChEMBL | GPCRScan assay: inhibition of Sigma 1 | B | 5.93 | pKi | 1180.59 | nM | Ki | Data for DCP probe PPTN |
ChEMBL | GPCRScan assay: inhibition of Sigma 1 | B | 5.93 | pKi | 1174.9 | nM | Ki | Data for DCP probe PPTN |
Uncharacterized protein in Pan troglodytes (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831325] [UniProtKB: A0A2J8P2M1] | ||||||||
ChEMBL | Antagonist activity against chimpanzee GPR105 expressed in stable HEK cells co-expressing chimeric G-protein Gqi5 assessed as inhibition of UDP-glucose-induced Ca2+ signaling response incubated for 20 mins by FLIPR assay | F | 8.66 | pIC50 | 2.2 | nM | IC50 | US-20100298347-A1. Substituted 2-naphthoic acids as antagonists of gpr105 activity (2010) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]