L-162,313 [Ligand Id: 3936] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL288174 (L-162313) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4607] [GtoPdb: 35] [UniProtKB: P50052] | ||||||||
| ChEMBL | Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement. | B | 8.55 | pKi | 2.8 | nM | Ki | J Med Chem (2004) 47: 1536-1546 [PMID:14998339] |
| ChEMBL | Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor | B | 8.55 | pKi | 2.8 | nM | Ki | J Med Chem (2004) 47: 5995-6008 [PMID:15537354] |
| ChEMBL | Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2004) 47: 1536-1546 [PMID:14998339] |
| ChEMBL | Inhibition of Angiotensin II receptor, type 2 | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1996) 39: 625-656 [PMID:8576904] |
| ChEMBL | Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2004) 47: 5995-6008 [PMID:15537354] |
| AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351] | ||||||||
| ChEMBL | Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem (2010) 18: 4570-4590 [PMID:20493713] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| GtoPdb | - | - | 7.92 | pIC50 | 11.9 | nM | IC50 | J Biol Chem (1995) 270: 1493-6 [PMID:7829475] |
| AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] | ||||||||
| ChEMBL | Displacement of [125I]Ang II from AT1 receptor in rat liver membranes | B | 8.41 | pKi | 3.9 | nM | Ki | J Med Chem (2020) 63: 1978-1995 [PMID:32030982] |
| ChEMBL | Displacement of [125]Ang2 from AT1 receptor in rat liver membrane | B | 8.96 | pKi | 1.1 | nM | Ki | Bioorg Med Chem (2008) 16: 6841-6849 [PMID:18599297] |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| GtoPdb | - | - | 7.92 | pIC50 | 11.9 | nM | IC50 | J Biol Chem (1995) 270: 1493-6 [PMID:7829475] |
| ChEMBL | Inhibition of Angiotensin II receptor, type 1 | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (1996) 39: 625-656 [PMID:8576904] |
| Type-1 angiotensin II receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5743] [UniProtKB: P30555] | ||||||||
| ChEMBL | Displacement of [125]Ang2 from AT2 receptor in pig uterus membrane | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem (2008) 16: 6841-6849 [PMID:18599297] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
