(S)-(+)-CBPG [Ligand Id: 3421] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL43412 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255] | ||||||||
| ChEMBL | Agonist potency against cloned human metabotropic glutamate receptor 1 | F | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2000) 43: 2609-2645 [PMID:10893301] |
| ChEMBL | Inhibitory activity against mGluR1 receptor | B | 4.49 | pIC50 | 32000 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1569-1574 [PMID:9873392] |
| ChEMBL | The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR1a | F | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1996) 39: 2874-2876 [PMID:8709120] |
| ChEMBL | Antagonist activity at mGlu1 receptor | F | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (2007) 50: 2563-2568 [PMID:17489573] |
| ChEMBL | Inhibition of mGluR1a receptor | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (2011) 54: 2529-2591 [PMID:21413808] |
| mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 67000 | nM | IC50 | Neuropharmacology (1999) 38: 917-26 [PMID:10428410] |
| ChEMBL | Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells. | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1999) 42: 1546-1555 [PMID:10229625] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| ChEMBL | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2005) 48: 2534-2547 [PMID:15801843] |
| mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| GtoPdb | - | - | 4.3 | pEC50 | 47000 | nM | EC50 | Neuropharmacology (1999) 38: 917-26 [PMID:10428410] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
