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ChEMBL ligand: CHEMBL157822 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cGMP-dependent protein kinase 1 alpha in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3183] [UniProtKB: P00516] | ||||||||
ChEMBL | Tested for inhibition of cGMP-dependent protein kinase from bovine lung | B | 5.32 | pIC50 | 4800 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 55-60 |
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746] | ||||||||
ChEMBL | Tested for inhibition of Myosin light chain kinase from chicken gizzard | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 55-60 |
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
GtoPdb | - | - | 5.8 | pKd | - | - | - | Mol Pharmacol (2000) 58: 194-207 [PMID:10860942] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 5 | pKd | - | - | - | Mol Pharmacol (2000) 58: 194-207 [PMID:10860942] |
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
GtoPdb | - | - | 5.1 | pKd | - | - | - | Mol Pharmacol (2000) 58: 194-207 [PMID:10860942] |
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
GtoPdb | - | - | 5.7 | pKd | - | - | - | Mol Pharmacol (2000) 58: 194-207 [PMID:10860942] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]