ChEMBL ligand: CHEMBL54004 (BPH-252)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!
Hexokinase in Trypanosoma cruzi [ChEMBL: CHEMBL4151] [UniProtKB: Q8ST54] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	6.64	pKi	230	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	5.62	pIC50	2400	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	5.63	pIC50	2344.23	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL	Inhibitory activity against Leishmania major Farnesyl diphosphate synthase	B	5.63	pIC50	2370	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Inhibitory activity against FPPS in Leishmania major	B	5.63	pIC50	2370	nM	IC50	J Med Chem (2006) 49: 215-223 [PMID:16392806]
ChEMBL	Inhibitory activity against FPPS in Leishmania major	B	5.63	pIC50	2344.23	nM	IC50	J Med Chem (2006) 49: 215-223 [PMID:16392806]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
GtoPdb	Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).	-	6.14	pIC50	720	nM	IC50	J Med Chem (2002) 45: 2185-96 [PMID:12014956]
ChEMBL	Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).	B	6.14	pIC50	720	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	6.15	pIC50	710	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
GtoPdb	Inhibition of human recombinant geranylgeranyl diphosphate synthase	-	6.15	pIC50	710	nM	IC50	J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	6.2	pIC50	630.96	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
Hexokinase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4151] [UniProtKB: Q8ST54]
ChEMBL	Inhibitory activity against Trypanosoma cruzi hexokinase	B	5.56	pIC50	2754.23	nM	IC50	J Med Chem (2006) 49: 215-223 [PMID:16392806]
ChEMBL	Inhibitory activity against Trypanosoma cruzi hexokinase	B	5.56	pIC50	2750	nM	IC50	J Med Chem (2006) 49: 215-223 [PMID:16392806]
ChEMBL	Inhibition of Trypanosoma cruzi hexokinase	B	6.09	pIC50	810	nM	IC50	J Biol Chem (2007) 282: 12377-12387 [PMID:17329254]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Inhibitory activity against Plasmodium berghei Ghana	F	5.7	pIC50	2000	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Inhibitory activity against Plasmodium berghei W2	F	6	pIC50	1000	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Inhibitory activity against Plasmodium berghei 3D7	F	6.08	pIC50	830	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Growth inhibition of Plasmodium falciparum	F	5.48	pIC50	3300	nM	IC50	J Med Chem (2008) 51: 7827-7833 [PMID:19053772]
ChEMBL	Growth inhibition of Plasmodium falciparum	F	5.5	pIC50	3162.28	nM	IC50	J Med Chem (2008) 51: 7827-7833 [PMID:19053772]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	In vitro growth inhibition against Plasmodium falciparum	F	6.08	pIC50	830	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 24 hrs followed by [3H]hypoxanthine addition by microbeta scintillation counter analysis	F	6.08	pIC50	830	nM	IC50	J Med Chem (2021) 64: 1260-1282 [PMID:33522236]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]