compound 16 [PMID: 18800762] [Ligand Id: 3195] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL494896
  • geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 6.46 pIC50 350 nM IC50 J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
GtoPdb Inhibition of human recombinant geranylgeranyl diphosphate synthase - 6.46 pIC50 350 nM IC50 J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 6.5 pIC50 316.23 nM IC50 J Med Chem (2008) 51: 5594-5607 [PMID:18800762]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]