compound 4q [PMID: 7650673] [Ligand Id: 3108] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL15929
  • squalene monooxygenase/Squalene monooxygenase in Human [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534]
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  • squalene synthase in Human [GtoPdb: 645] [UniProtKB: P37268]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
squalene monooxygenase/Squalene monooxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534]
ChEMBL In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring the extend of cholesterol radiolabeling after incubation with [14C]mevalonate B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (1997) 7: 1153-1156
ChEMBL In vitro inhibitory activity against pig liver microsomal squalene epoxidase F 7.7 pIC50 20 nM IC50 J Med Chem (1995) 38: 3207-3216 [PMID:7650673]
squalene synthase in Human [GtoPdb: 645] [UniProtKB: P37268]
GtoPdb In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]-mevalonate. - 7.22 pIC50 60 nM IC50 J Med Chem (1995) 38: 3207-16 [PMID:7650673]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]