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ChEMBL ligand: CHEMBL15929 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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squalene monooxygenase/Squalene monooxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534] | ||||||||
ChEMBL | In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring the extend of cholesterol radiolabeling after incubation with [14C]mevalonate | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1153-1156 |
ChEMBL | In vitro inhibitory activity against pig liver microsomal squalene epoxidase | F | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1995) 38: 3207-3216 [PMID:7650673] |
squalene synthase in Human [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
GtoPdb | In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]-mevalonate. | - | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (1995) 38: 3207-16 [PMID:7650673] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]