compound 1c [Brown et al., 1997] [Ligand Id: 3105] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL24362 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| ChEMBL | Inhibition of compound was measured on rat microsomal Oxidosqualene-lanosterol cyclase | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
| squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
| ChEMBL | Tested for its inhibitory activity against human microsomal quinuclidine squalene synthase (SQS) | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 597-600 |
| GtoPdb | Tested for its inhibitory activity against human microsomal quinuclidine squalene synthase (SQS) | - | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 597-600 |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS) | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 597-600 |
| ChEMBL | Compound was measured for the inhibition of rat microsomal squalene synthase enzyme | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
