compound 1 [Overhand et al., 1997] [Ligand Id: 3065] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL86513 ((2E,6E)-Farnesylbisphosphonate, 2E,6E-Farnesyl Bisphosphonate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
| ChEMBL | Inhibition of GST-tagged human recombinant GGDPS expressed in BL21 gold bacteria | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2008) 16: 390-399 [PMID:17905588] |
| ChEMBL | Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2008) 16: 3652-3660 [PMID:18308574] |
| squalene synthase in Human [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
| GtoPdb | Inhibition of Squalene Synthase | - | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2435-2440 |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Inhibition rat liver microsomal squalene synthase | B | 7.49 | pIC50 | 32.4 | nM | IC50 | J Med Chem (1995) 38: 2596-2605 [PMID:7629799] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
