baicalin [Ligand Id: 13076] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL485818 (Baicalin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat | F | 5.1 | pKi | 7950 | nM | Ki | Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of Cdk1/cyclin B | B | 4.84 | pIC50 | 14360 | nM | IC50 | Bioorg Med Chem (2008) 16: 7128-7133 [PMID:18639462] |
| GABAA receptor π subunit/GABAA receptor δ subunit/GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor ε subunit/GABAA receptor α6 subunit/GABAA receptor γ1 subunit/GABAA receptor γ3 subunit/GABAA receptor θ subunit/GABA-A receptor; anion channel in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093872] [GtoPdb: 419, 416, 404, 410, 414, 412, 408, 406, 405, 411, 407, 417, 409, 413, 415, 418] [UniProtKB: O00591, O14764, P14867, P18505, P18507, P28472, P31644, P34903, P47869, P47870, P48169, P78334, Q16445, Q8N1C3, Q99928, Q9UN88] | ||||||||
| ChEMBL | Binding affinity towards benzodiazepine site in GABAA receptor | B | 4.11 | pKi | 77624.71 | nM | Ki | J Med Chem (2001) 44: 1883-1891 [PMID:11384234] |
| lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] | ||||||||
| ChEMBL | Inhibition of LSD1 (unknown origin) | B | 5.45 | pIC50 | 3550 | nM | IC50 | Bioorg Med Chem (2019) 27: 370-374 [PMID:30552007] |
| ChEMBL | Inhibition of LSD1 (unknown origin) expressed in human MGC-803 cells incubated for 5 days by DAPI staining based immunofluorescence method | B | 5.52 | pIC50 | 3010 | nM | IC50 | RSC Med Chem (2020) 11: 969-981 [PMID:33479691] |
| ChEMBL | Inhibition of LSD1 (unknown origin) | B | 5.52 | pIC50 | 3010 | nM | IC50 | Eur J Med Chem (2021) 220: 113501-113501 [PMID:33945992] |
| prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] | ||||||||
| ChEMBL | Inhibition of human recombinant POP | B | 4.91 | pIC50 | 12300 | nM | IC50 | J Med Chem (2010) 53: 3423-3438 [PMID:20058865] |
| ChEMBL | Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7516-7524 [PMID:18650094] |
| Cyclic GMP-AMP synthase in Human [GtoPdb: 3165] [UniProtKB: Q8N884] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | 3970 | nM | IC50 | Bioorg Chem (2023) 140: 106802 [PMID:37666112] |
| Cyclic GMP-AMP synthase in Mouse [GtoPdb: 3165] [UniProtKB: Q8C6L5] | ||||||||
| GtoPdb | - | - | 4.96 | pIC50 | 10840 | nM | IC50 | Bioorg Chem (2023) 140: 106802 [PMID:37666112] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
