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ChEMBL ligand: CHEMBL2334586 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase kinase kinase 14/Mitogen-activated protein kinase kinase kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5888] [GtoPdb: 2074] [UniProtKB: Q99558] | ||||||||
GtoPdb | Enzymatic inhibition determined in a homogenous time resolved fluorescence (HTRF) assay for NIK (MAP3K14) | - | 6 | pKi | <1000 | nM | Ki | WO2009158011A1. Alkynyl alcohols as kinase inhibitors (2009) |
ChEMBL | Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 stimulation measured after 5 hrs | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1238-1244 [PMID:23374866] |
ChEMBL | Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay | B | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1238-1244 [PMID:23374866] |
p21 (RAC1) activated kinase 4 in Human [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
GtoPdb | - | - | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
p21 (RAC1) activated kinase 6 in Human [GtoPdb: 2137] [UniProtKB: Q9NQU5] | ||||||||
GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
p21 (RAC1) activated kinase 5 in Human [GtoPdb: 2138] [UniProtKB: Q9P286] | ||||||||
GtoPdb | - | - | 7.02 | pIC50 | 96 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
TAO kinase 1 in Human [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
TAO kinase 2 in Human [GtoPdb: 2234] [UniProtKB: Q9UL54] | ||||||||
GtoPdb | - | - | 7.04 | pIC50 | 91 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
TAO kinase 3 in Human [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
GtoPdb | - | - | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
tau tubulin kinase 1 in Human [GtoPdb: 2262] [UniProtKB: Q5TCY1] | ||||||||
GtoPdb | - | - | 6.7 | pIC50 | 199 | nM | IC50 | J Med Chem (2021) 64: 6358-6380 [PMID:33944571] |
phosphoinositide kinase, FYVE-type zinc finger containing in Human [GtoPdb: 2857] [UniProtKB: Q9Y2I7] | ||||||||
GtoPdb | - | - | 8.66 | pIC50 | 2.2 | nM | IC50 | J Med Chem (2022) 65: 12860-12882 [PMID:36111834] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]