ensifentrine [Ligand Id: 11865] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4594287 (Ensifentrine, Ls-193,855, Ls-193855, RPL-554, RPL554) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| GtoPdb | Inhibition of PDE3 from human platelets | - | 9.4 | pIC50 | 0.4 | nM | IC50 | J Pharmacol Exp Ther (2006) 318: 840-8 [PMID:16682455] |
| phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| GtoPdb | Inhibition of PDE4 obtained from human neutrophils | - | 5.83 | pIC50 | 1479 | nM | IC50 | J Pharmacol Exp Ther (2006) 318: 840-8 [PMID:16682455] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
