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ChEMBL ligand: CHEMBL523435 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
ChEMBL | Inhibition of CDK1/Cyclin B | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2009) 52: 1853-1863 [PMID:19338355] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2/Cyclin A | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2009) 52: 1853-1863 [PMID:19338355] |
ChEMBL | Inhibition of CDK2/Cyclin E | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2009) 52: 1853-1863 [PMID:19338355] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human GSK3-beta by scintillation counting | B | 6.61 | pIC50 | 247 | nM | IC50 | J Med Chem (2009) 52: 1853-1863 [PMID:19338355] |
GtoPdb | In a cell-free assay. | - | 6.61 | pIC50 | 247 | nM | IC50 | J Med Chem (2009) 52: 1853-63 [PMID:19338355] |
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
ChEMBL | Inhibition of IKKalpha | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2009) 52: 1853-1863 [PMID:19338355] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2009) 52: 1853-1863 [PMID:19338355] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]