tenofovir [Ligand Id: 10948] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL483 (Atripla, GS-1275, PMP-A, Tenofovir, Truvada)
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Core antigen in Hepatitis B virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075091] [UniProtKB: Q03732]
ChEMBL Inhibition of hepatitis B virus capsid assembly infected in human HepG2.215 cells assessed as reduction in viral DNA replication measured on day 7 by real time PCR analysis B 6.62 pEC50 241.5 nM EC50 Bioorg Med Chem (2017) 25: 1042-1056 [PMID:28082068]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrate B 5.49 pKd 3200 nM Kd Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852]
ChEMBL Inhibition of HIV1 reverse transcriptase B 6.42 pIC50 380 nM IC50 Bioorg Med Chem (2007) 15: 5519-5528 [PMID:17562366]
ChEMBL Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells B 6.42 pIC50 380 nM IC50 Bioorg Med Chem Lett (2008) 18: 1120-1123 [PMID:18164198]
ChEMBL Inhibition on HIV1 reverse transcriptase p66/p51 B 6.42 pIC50 380 nM IC50 Bioorg Med Chem (2009) 17: 1739-1746 [PMID:19179082]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]