diminazene [Ligand Id: 10307] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL35241 (4,4'-(diazoamino)benzamidine, Diminazen, Diminazene) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - |
Br J Pharmacol (2018) 175: 2204-2218 [PMID:29134638]; PLoS One (2018) 13: e0196894 [PMID:29782492]; Mol Pharmacol (2017) 92: 665-675 [PMID:29025967] |
| ASIC1/Acid-sensing ion channel 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232694] [GtoPdb: 684] [UniProtKB: Q6NXK8] | ||||||||
| ChEMBL | Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | B | 4.24 | pIC50 | 56900 | nM | IC50 | ACS Med Chem Lett (2019) 10: 627-632 [PMID:30996808] |
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of human liver cathepsin B | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2008) 51: 545-552 [PMID:18173229] |
| Diamine oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2118] [UniProtKB: P19801] | ||||||||
| ChEMBL | Mixed type inhibition of recombinant human DAO expressed in drosophila S2 cells | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem (2014) 22: 1983-1992 [PMID:24630693] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake | F | 6.72 | pIC50 | 190 | nM | IC50 | Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298] |
| Spermidine/spermine N(1)-acetyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4286] [UniProtKB: P21673] | ||||||||
| ChEMBL | Inhibition of human SSAT using spermidine as substrate | B | 5.62 | pKi | 2400 | nM | Ki | Bioorg Med Chem (2014) 22: 1983-1992 [PMID:24630693] |
| ASIC2 in Human [GtoPdb: 685] [UniProtKB: Q16515] | ||||||||
| GtoPdb | - | - | 6.1 | pIC50 | - | - | - | Br J Pharmacol (2018) 175: 2204-2218 [PMID:29134638] |
| ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Br J Pharmacol (2018) 175: 2204-2218 [PMID:29134638] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
