Figure 1. A, phylogenetic tree of mammalian cyclic nucleotide-regulated cation channels. B, domain structure of CNG and HCN channel subunits. 1-6, transmembrane helices; P, pore-loop harboring the ion selectivity filter; C-linker (C-terminal linker domain); CNBD, cyclic nucleotide binding domain. The dotted arrow indicates the flow of cations through the pore. C, channel tetramer.
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