STAT transcription factors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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STAT family transcription factor proteins are phosphorylated by receptor kinases that are the receptors for cytokines and growth factors. Homo- or heterodimer phospho-STATs then translocate to the nucleus to regulate transcription of responsive genes.

Targets

Targets of relevance to immunopharmacology are highlighted in blue

STAT3 (signal transducer and activator of transcription 3) Show summary » More detailed page

STAT6 (signal transducer and activator of transcription 6) Show summary » More detailed page

How to cite this family page

Database page citation:

STAT transcription factors. Accessed on 19/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=990.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.