Riboflavin, also known as vitamin B2, is a precursor of the enzyme cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Riboflavin transporters are predicted to possess 10 or 11 TM segments.

Although expressed elsewhere, RFVT3 is found on the luminal surface of intestinal epithelium and is thought to mediate uptake of dietary riboflavin, while RFVT1 and RFVT2 are thought to allow movement from the epithelium into the blood.

* Key recommended reading is highlighted with an asterisk

Yamamoto S, Inoue K, Ohta KY, Fukatsu R, Maeda JY, Yoshida Y, Yuasa H. (2009) Identification and functional characterization of rat riboflavin transporter 2. J Biochem, 145 (4): 437-43. [PMID:19122205]

* Yonezawa A, Inui K. (2013) Novel riboflavin transporter family RFVT/SLC52: identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52. Mol Aspects Med, 34 (2-3): 693-701. [PMID:23506902]

1. Yao Y, Yonezawa A, Yoshimatsu H, Masuda S, Katsura T, Inui K. (2010) Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. J Nutr, 140 (7): 1220-6. [PMID:20463145]