Dyrk1 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) Show summary »« Hide summary More detailed page go icon to follow link

DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B) Show summary »« Hide summary More detailed page go icon to follow link

DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2013

Nomenclature

dual specificity tyrosine phosphorylation regulated kinase 4

Common abbreviation

DYRK4

Previous and unofficial names

RAD51 associated protein 1 | Rad51ap1 | dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Genes

DYRK4 (Hs), Dyrk4 (Mm), Dyrk4 (Rn)

Ensembl ID

ENSG00000010219 (Hs), ENSMUSG00000030345 (Mm), ENSRNOG00000053178 (Rn)

UniProtKB AC

Q9NR20 (Hs), Q8BI55 (Mm)

EC number

2.7.12.1

References

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1. Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP. (2013) Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. Eur J Med Chem, 62: 728-37. [PMID:23454515]

2. Coombs TC, Tanega C, Shen M, Wang JL, Auld DS, Gerritz SW, Schoenen FJ, Thomas CJ, Aubé J. (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett, 23 (12): 3654-61. [PMID:23642479]

3. Kettle JG, Ballard P, Bardelle C, Cockerill M, Colclough N, Critchlow SE, Debreczeni J, Fairley G, Fillery S, Graham MA et al.. (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem, 58 (6): 2834-44. [PMID:25738750]

4. Leblond B, Casagrande A-S, Desire L, Foucourt A, Besson T. (2013) Dyrk1 inhibitors and uses thereof. Patent number: WO2013026806. Assignee: Exonhit Sa. Priority date: 19/08/2011. Publication date: 28/02/2013.

5. Rosse G. (2013) Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett, 4 (6): 502-3. [PMID:24900699]

How to cite this family page

Database page citation:

Dyrk1 subfamily. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=503.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.