CRK7 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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CDK12 and CDK13 are C-terminal domain (CTD) serine kinases that phosphorylate Ser2 in the CTD of RNA polymerase II and which regulate co-transcriptional processing, including splicing and 3'-end RNA processing [1,3-5]. Although CDK12 and CDK13 are closely related structurally, they differ in function. Whilst CDK12 is essential for the expression of genes that are involved in the DNA damage response pathway [2] (generally longer genes with a high number of exons), CDK13 activity affects genes that are required for protein translation.

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

CDK12 (cyclin dependent kinase 12) Show summary » More detailed page

CDK13 (cyclin dependent kinase 13) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

CRK7 subfamily. Accessed on 24/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=490.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.