Type VIII RTKs: ROR family | Catalytic receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

Type VIII RTKs: ROR family C

Formerly known as: ROR family and other RTKs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of the ROR family appear to be activated by ligands complexing with other cell-surface proteins. Thus, ROR1 and ROR2 appear to be activated by Wnt-5a (WNT5A, P41221) binding to a Frizzled receptor thereby forming a cell-surface multiprotein complex [1].

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

ROR1 (receptor tyrosine kinase like orphan receptor 1) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1845

Nomenclature

receptor tyrosine kinase like orphan receptor 1

Common abbreviation

ROR1

Previous and unofficial names

NTRKR1 | neurotrophic tyrosine kinase, receptor-related 1

Genes

ROR1 (Hs), Ror1 (Mm), Ror1 (Rn)

Ensembl ID

ENSG00000185483 (Hs), ENSMUSG00000035305 (Mm), ENSRNOG00000029449 (Rn)

UniProtKB AC

Q01973 (Hs), Q9Z139 (Mm)

EC number

2.7.10.1

ROR2 (receptor tyrosine kinase like orphan receptor 2) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1846

Nomenclature

receptor tyrosine kinase like orphan receptor 2

Common abbreviation

ROR2

Previous and unofficial names

BDB | BDB1 | NTRKR2 | Neurotrophic tyrosine kinase, receptor-related 2

Genes

ROR2 (Hs), Ror2 (Mm), Ror2 (Rn)

Ensembl ID

ENSG00000169071 (Hs), ENSMUSG00000021464 (Mm), ENSRNOG00000053232 (Rn)

UniProtKB AC

Q01974 (Hs), Q9Z138 (Mm)

EC number

2.7.10.1

References

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How to cite this family page

Database page citation:

Type VIII RTKs: ROR family . Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=332.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.